12/15/2023 0 Comments Download calcium and vitamin d3![]() ![]() Experimental animal studies have indicated that vitamin D 2 is less toxic than vitamin D 3, but this has not been demonstrated in humans. When activated, the D 2 and D 3 forms have been reported to exhibit identical responses in the body, and the potency related to the ability to cure vitamin D–deficiency rickets is the same ( Fieser and Fieser, 1959 Jones et al., 1998 Jurutka et al., 2001). The differences do not affect metabolism (i.e., activation), and both forms function as prohormones. The D 2 and D 3 forms differ only in their side chain structure. Both vitamin D 3 and vitamin D 2 are synthesized commercially and found in dietary supplements or fortified foods. Vitamin D 2 (ergocalciferol) is largely human-made and added to foods, whereas vitamin D 3 (cholecalciferol) is synthesized in the skin of humans from 7-dehydrocholesterol and is also consumed in the diet via the intake of animal-based foods. The two major forms are vitamin D 2 and vitamin D 3. Vitamin D, also known as calciferol, comprises a group of fat-soluble seco-sterols. These dual sources of vitamin D make it challenging to develop dietary reference intake values. ![]() A unique aspect of vitamin D as a nutrient is that it can be synthesized by the human body through the action of sunlight. Vitamin D, first identified as a vitamin early in the 20th century, is now recognized as a prohormone. ![]()
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